Kerlikowske K, et al. - Via a cohort study of 638,856 women aged 40 to 74 years who had 1,693,163 screening digital mammograms taken at Breast Cancer Surveillance Consortium (BCSC) imaging facilities from January 3, 2005, to December 31, 2014, the researchers intended to recognize ladies at high risk of advanced breast cancer in order to target woman-practitioner discussions about the necessity for supplemental imaging. Women with dense breasts accounted for 47.0% and 60.0% of screened women and advanced cancers, respectively. In screened women with dense breasts, low advanced cancer rates happened in 34.5%. High advanced breast cancer rates happened in women with heterogeneously dense breasts and 5-year risk of 2.5% or greater and those with remarkably dense breasts and 5-year risk of 1.0% or higher. Density-risk subgroups at high advanced cancer risk involved 12.5% and 27.1% of screened women and advanced cancers, respectively. In comparison with a strategy based on dense breasts, density-risk subgroups were observed having less supplemental imaging discussions per potential advanced cancer limited. Huge rates of false-positive short-interval follow-up recommendation without experiencing supplemental imaging were observed in women with heterogeneously dense breasts and a 5-year risk less than 1.67%. Hence, breast density notification should be blended with breast cancer risk, so that women at the greatest risk for advanced cancer are targeted for supplemental imaging discussions and women at lesser risk are not. Furthermore, for supplemental imaging discussions than targeting all women with dense breasts, Breast Imaging Reporting, and Data System breast density when combined with BCSC 5-year risk could give a more effective approach.