Tao JX, et al. - This study was performed to ascertain the outcomes of combined stereo-electroencephalography-guided and MRI-guided stereotactic laser interstitial thermal therapy (LITT) in the treatment of patients with drug-resistant mesial temporal lobe epilepsy (mTLE). For mTLE with mesial temporal sclerosis (MTS), MRI-guided LITT was a safe and effective alternative to selective amygdalohippocampectomy and anterior temporal lobectomy. Although, its efficacy in those without MTS seemed modest.