Markus HS, et al. – In the Vertebral Artery Ischaemia Stenting Trial (VIST), the researchers aimed to compare the risks and benefits of vertebral angioplasty and stenting with best medical treatment (BMT) alone for symptomatic vertebral artery stenosis. With low complication rates, stenting in extracranial stenosis appeared safe. To determine whether stenting reduces stroke risk, a large phase 3 trials were required.