Kim ML, et al. – This study is performed to examine the impacts of statins on transforming growth factor–β 2 (TGF–β2)–induced expression of extracellular matrix (ECM) proteins in human astrocytes of the optic nerve head (ONH) lamina cribrosa (LC). According to the outcomes obtained, they observed an anti–fibrotic impact of statins in human astrocytes of the ONH and identified TGF–β2 as a mediator of statin action, which may support a beneficial role for statins in blocking glaucomatous axonal damage induced by ECM remodeling.