Jun JE, et al. - In this nested case-control study conducted in Korea, researchers investigated the benefits of statins for primary prevention of cardiovascular disease (CVD) and all-cause death in adults aged ≥ 75 years. Taking into account the duration of follow-up, age, and sex at the index date, 11,017 individuals who developed CVD— including myocardial infarction (MI), stroke, or death from all causes—were matched to 55,085 control subjects. The investigators noted a significant link between current use of statins and attenuated risk of the composite outcome vs non-users. With the current use of statin, a reduction in the risk of stroke and of all-cause death, but not in MI, was also noted. There was no effect of the former use of statins on CVD or all-cause death. In this study population, primary prevention with current statin treatment had a beneficial effect for composite outcomes and individual event of stroke or all-cause death.