Jun JE, Jeong IK, Ahn KJ, et al. - It was shown that statin indicated a protective effect against cardiovascular diseases and all-cause death in type 2 diabetes; this effect was decreased beyond the age of 75 years and disappeared in young patients aged <40 years.

• In this propensity score-matched cohort, researchers recruited a total of 168,045 statin users and 168,045 non-users (mean age 57 years; median follow-up 5.0 years).

• The results demonstrated that in comparison with statin non-users, the hazard ratio was 0.72 (95% confidence interval [CI] 0.70 – 0.73; P<0.001) for composite outcomes, 0.80 (0.76 - 0.84; P<0.001) for MI, 0.74 (0.71 – 0.76; P<0.001) for stroke, and 0.68 (0.66 – 0.70; P<0.001) for all-cause death in statin users.

• In patients aged 40-74 years, the risk reduction was most prominent, attenuated but significant in those aged ≥ 75 years, and not significant in those aged < 40 years.