Shi M, et al. - This research was executed in order to explore the link between STAT3 mutational status with patients’ clinical, histopathologic, and other laboratory features in T-cell large granular lymphocytic leukemia (T-LGLL). Results did not exhibit any notable variations in the complete blood count, flow cytometric immunophenotypic features, T-cell receptor γ V-J rearrangement repertoire, and bone marrow biopsy morphology among the STAT3-mutation and wild-type groups, with the exception of considerably larger tumor burden in patients with STAT3 mutations. An advanced research was required to elucidate the underlying mechanisms for the distinct disease association and therapeutic responses in patients with mutant and wild-type STAT3. The yielded data underscored the significance of detecting STAT3 mutational status in patients with T-LGLL, which could aid in clinical therapeutic choice.