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Starting dose of sorafenib for the treatment of hepatocellular carcinoma: a retrospective, multi-institutional study

Journal of Clinical Oncology Nov 08, 2017

Reiss KA et al. -Sorafenib is first-line therapy for advanced hepatocellular carcinoma; however, the starting dose has not been established. In the current study, sorafenib therapy at ra educed dose was shown to be associated with reduced pill use, reduced costs, and a decreased discontinuation rate. Importantly, reduced dosing was not associated with decreased overall survival.

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