Kop E, de Bock GH, Noordhuis MG, et al. - In this investigation involving 208 patients, researchers illustrated the predictive value of the Ki-67 PI for LC and disease specific survival (DSS) utilizing a well-defined series of T1-T2 LSCC, standardized automatic immunostaining and digital image analysis (DIA). Selected a consecutive and well-defined cohort of primary RT-treated patients with T1-T2 LSCC. Using DIA, the Ki-67 PI was determined. To evaluate connections between Ki-67 PI, clinicopathological variables, LC and DSS, Mann Whitney U tests, logistic and Cox regression analyses were performed. Independent predictors for LC were poor tumour differentiation and alcohol use in multivariate Cox regression analysis. An independent predictor for DSS was lymph node positivity. The Ki-67 PI was not found to be a predictor of LC or DSS and should therefore not be integrated into LSCC decision-making related to treatment.