Kop E, de Bock GH, Noordhuis MG, et al. - In a well-defined consecutive series of patients with early-stage (T1-T2) laryngeal squamous cell cancer (LSCC), researchers assessed the value of Ki-67 proliferation index (Ki-67 PI) in anticipating local control (LC) and disease-specific survival (DSS) after primary radiotherapy (RT). A consecutive and well-defined cohort of 208 individuals with T1-T2 LSCC treated with primary RT has been chosen. To evaluate connections between Ki-67 PI, clinicopathological variables, LC and DSS, Mann-Whitney U-tests, logistic and Cox regression analyses were performed. Independent predictors for LC were poor tumour differentiation and alcohol use, defined as drinking one or more units per day either in the past or at the date of diagnosis, in multivariate Cox regression analysis. An independent predictor for DSS was lymph node positivity. The Ki-67 PI has not been shown to be a predictor of LC or DSS and should therefore not be integrated into LSCC decision-making related to treatment.