Chapalain M, Baroudjian B, Dupont A, et al. - Researchers conducted a retrospective study to examine the clinical features and treatment outcomes in stage IV cutaneous squamous cell carcinoma (cSCC) with unresectable locoregional extension and/or the presence of metastases. This investigation was carried out at a single-center university hospital for stage IV cSCC patients followed between January 1, 2008, and December 31, 2015. Participants in the study included 42 patients (median age: 75.5 years) with stage IV cSCC who were treated with ≥ 1 line of chemotherapy and/or cetuximab. According to findings, very poor prognosis of stage IV cSCC and a poor response to conventional therapies were confirmed, suggesting that the stage IV cSCC patient population remains with unmet medical needs.