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Stage-dependent conditional survival and failure hazard of non-metastatic nasopharyngeal carcinoma after intensity-modulated radiation therapy: Clinical implications for treatment strategies and surveillance

Cancer Medicine May 28, 2021

Wang J, Huang X, Sun S, et al. - The present study was conducted to evaluate the conditional survival and dynamic failure hazard in non-metastatic nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy. Researchers estimated conditional overall survival and progression-free survival estimates adjusted for age and gender against each AJCC 8th stage. They further calculated annual hazard rates of death and progression over 10 years for each stage. A total of 1993 patients were included in this study. The results of this study demonstrate that the survival prospect of non-metastatic NPC improves over years with distinct dynamic patterns across stages, providing important implications for personalized decision-making in terms of both clinical management and surveillance counseling. There is a need for stage-dependent and hazard-adapted clinical management and surveillance.

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