Ng MSN, So WKW, Wong CL, et al. - In this longitudinal study, patients with end-stage renal disease undergoing dialysis were examined for the stability of symptom clusters and for their influence on health-related quality of life and functional status over a period of one year in these cases. Using Dialysis Symptom Index, Kidney Disease Quality of Life 36, and Karnofsky Performance Status Scale, the impacts of symptom clusters and outcomes were examined. Among 271 patients on dialysis who completed the 12-month assessment, symptoms clustered in relatively stable patterns. Across the three assessments, four symptom clusters—namely, uremic, gastrointestinal, skin, and emotional— were identified. Various aspects of patients' well-being were consistently negatively influenced by the four symptom clusters. Researchers noted a correlation of a higher uremic cluster factor score with poorer physical well-being, whereas there was a consistent correlation of higher emotional cluster factor score with poorer mental well-being. Findings thereby emphasize the necessity for continuous symptom evaluation and early identification of symptoms that may contribute to adverse patient outcomes.