Rothstein TL - Whether median nerve somatosensory evoked potentials (SSEPs) and bilateral loss of the N20 cortical wave could be predictive for unfavorable outcome in comatose patients after cardiac arrest (CA) in the therapeutic hypothermia (TH) era, was re-assessed in this study. The researcher analyzed the findings as well as inferences formed from isolated case reports and small series of comatose patients post-CA, wherein, the bilateral absence of N20 response has been related to recovery. Findings revealed that in the assessment of patients with severe anoxic-ischemic encephalopathy, the absence of the SSEP N20 cortical wave continued to be one of the most reliable early prognostic instruments for detecting an unfavorable neurologic outcome irrespective of the receipt of TH. The false positive rate approached zero when confounding factors were excluded.