Sierra‐Colomina M, et al. - In this single‐center, prospective, observational study, researchers sought to measure serum sRAGE (soluble receptor for advanced glycation end-products) in infants with severe acute bronchiolitis (AB) and to evaluate its association with clinical severity, immediate complications, and outcome. The sample consisted of hospitalized children with severe bronchiolitis admitted to the Pediatric Intensive Care Unit (PICU), from September 2015 to September 2016. In total, 52 children and 27 controls were involved. Findings suggested that sRAGE in children hospitalized at PICU could not predict AB severity or outcome. However, it increased significantly in the presence of any lung consolidation and had a strong correlation with classical biomarkers. In this population, the utility of sRAGE could be probably elucidated with a better understanding of the AGE-RAGE axis.