Rossignol P, et al. - The effectiveness of spironolactone in improving blood pressure (BP) control in patients with heart failure with preserved ejection fraction (HFpEF) and resistant hypertension (RHTN) was investigated in this study. With spironolactone, substantial reductions in BP were seen in HFpEF patients with RHTN. Furthermore, spironolactone was associated with similar benefit in these subjects as those without RHTN.