Ghisi D, Boschetto G, Spinelli AM, et al. - Patients receiving procedures of the lower extremities were analyzed in this prospective, randomised, observer-blinded study to assess the time to complete block resolution of 2-chloroprocaine 1% at three intrathecal doses (30, 40 and 50 mg). Participants were 45 patients, aged 18–65 years, American Society of Anaesthesiologists score I-II, BMI 18–32 kg/m ² , receiving elective lower limb procedures lasting ≤ 40 min and with a requested dermatomeric level of sensory block ≥ T12. In a 1:1:1 ratio, participants were randomly assigned to receive Chloroprocaine HCl 1% at one of the three different intrathecal doses (Group 30 = 30 mg, Group 40 = 40 mg or Group 50 = 50 mg). According to findings, a longer resolution of spinal block was provided by doses of 50 mg and 40 mg vs the dose of 30 mg. Nevertheless, the dose of 30 mg led to a higher secondary failure rate.