Kim J - This research analyzed the effect of Spermidine, a naturally occurring polyamine on the proximal tubular cells from oxidative stress and necrosis after ischemic acute kidney injury. The findings displayed that spermidine level identified the kidney proximal tubular damage through oxidative stress and necrosis induced by ischemia and reperfusion injury (IRI). Hence, it served as a novel target for the prevention of tubular damage induced by IRI.