Renzini MM, Canto MD, Guglielmo MC, et al. - Researchers investigated if sperm donation can improve live birth rates following ICSI in advanced maternal age (AMA) patients via performing a retrospective multicenter cohort study. Data generated from 755 ICSI cycles achieving a fresh embryo transfer were included; of these, 337 were first homologous cycles (normozoospermic partner sperm and homologous oocytes) and 418 were first sperm donation cycles (donor sperm and homologous oocytes). Findings from the multivariate analysis suggest a positive correlation of sperm donation with the likelihood of a live birth, independent of all other variables tested in AMA (≥ 37 years, n = 477), but not in non-AMA patients (< 37 years, n = 278). Sperm donation was identified improving live birth rates while lowering miscarriage occurrence in AMA patients, and thus is suggested to be a valid strategy to improve ICSI outcomes in this growing and challenging patient group.