Young CD, et al. - Researchers intended to shed light on how which sperm capture HIV-1 on their surface and then deliver HIV-1 to vaginal/cervical epithelial cells that line the lower female reproductive tract as a first step in HIV-1 transmission. They incubated sperm from healthy donors with dual-tropic HIV-1_CS204 (clinical isolate) and used p24 antigen ELISA to determine virus capture. According to findings, sperm could capture HIV-1 in a dose-dependent manner, and sperm sulfogalactosylglycerolipid was implicated in this capture. Since HIV-1 remained infectious and was able to be transmitted into vaginal/cervical epithelial cells, the importance of sperm in HIV transmission is suggested.