Apostolopoulou M, et al. - The tie-up between sphingolipids with hepatic and peripheral metabolism was comprehensively investigated among 21 insulin-resistant obese patients without (NAFL-) or with (NAFL+) and nonalcoholic steatohepatitis (NASH), and 7 healthy lean individuals undergoing tissue biopsies during bariatric or elective abdominal surgery. Using hyperinsulinemic-euglycemic clamps with d-[6,6-2H2]glucose, researchers attempted to quantify tissue-specific insulin sensitivity. A rise was noted in sphingolipid species in insulin-resistant humans with NASH. However, it appeared to be related to hepatic oxidative stress and inflammation. This data indicated that such lipids possibly played a role during the progression of simple steatosis to NASH in humans.