Bao J, Närhi K, Teodòsio A, et al. - To understand the precise role of the transcription factor SOX9 in the progression of non-small cell lung cancer (NSCLC) histopathologies, this study was undertaken. Researchers found that SOX9 expression is associated with poor overall survival as well as invasive histopathology in human non-mucinous adenocarcinoma. In murine early minimally invasive and low in human in situ adenocarcinoma, absence of SOX9 expression was evident. Based on observations, it was concluded that SOX9 has histopathology-selective roles in the progression of NSCLC, namely as a promoter for papillary adenocarcinoma progression, but opposing metastasis-suppressing role in squamous histotype tissue. This attests to a pleiotropic SOX9 role, associated with the cell of origin as well as microenvironmental tissue contexts.