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Sonographically diagnosed urothelial thickening in kidney allografts: A noninvasive and clinically highly relevant marker for the detection of acute rejection

American Journal of Roentgenology Feb 29, 2020

Fananapazir G, Navarro SM, Zhou C, et al. - This study intended to investigate the significance of sonographic features in evaluating acute kidney allograft rejection in the modern era. Researchers designed a retrospective study including a total of 107 adult individuals with a kidney allograft biopsy between 2015 and 2018 and diagnostic ultrasound done within 2 weeks of the biopsy. Using the Banff criteria, acute rejection was diagnosed based on biopsy tissue sample results. The outcomes displayed that urothelial thickening on ultrasound is a highly sensitive finding for acute kidney rejection with a high NPV and therefore may play a role in sonographic prebiopsy screening. Other historically correlated sonographic features appear to play little whether any, role in the screening and evaluation for kidney allograft rejection in the modern era.
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