Ramírez-Ramírez R, Gutiérrez-Angulo M, Peregrina-Sandoval J, et al. - Given the involvement of KDM1A/LSD1, and ZNF217 in a protein complex that participates in transcriptional regulation and an association of ZNF217 amplification with advanced stages of disease in numerous cancers, researchers here examined tissue samples from patients diagnosed with colorectal cancer (CRC) for the number of KDM1A/LSD1 and ZNF217 gene copies. Further, they investigated its correlation with clinicopathological features in patients with CRC. They used fluorescence in situ hybridisation to ascertain the number of copies of KDM1A/LSD1 and ZNF217 genes in paraffin-embedded tumor samples from 50 patients with CRC with a histopathological diagnosis of CRC. Nineteen samples (38%) exhibited the deletion of the KDM1A/LSD1 gene, whereas 11 samples (22%) exhibited ZNF217 gene amplification. A significant correlation was observed between lymph node metastasis or advanced tumor stage and KDM1A/LSD1 gene deletion. These findings support considering KDM1A/LSD1 gene deletion as a valuable novel prognostic biomarker of late-stage CRC.