Tseng CCS, et al. - Herein, experts intended to inspect the soluble supressor of tumorigenicity 2 (sST2) levels in end-stage heart failure (HF) as well as the effect of unloading by left ventricular assist device (LVAD) support on sST2 levels. Levels of sST2 were found to be elevated and exhibited variability which indicated multiple inputs to a pro-inflammatory and pro-fibrotic pathway. A correlation was demonstrated between cardiogenic shock and increased CRP levels with higher sST2 levels. It was determined that LVAD support led to a notable drop in sST2 levels with normalization within 3 months post-implantation, which indicated that LVAD support caused a lessening of fibrosis and inflammation, possibly useful for targeting medical policy: Explantation of the LVAD vs permanent use or cardiac transplantation.