Yoshihisa A, et al. - In 79 pulmonary hypertension (PH) patients (mean pulmonary artery pressure ≥ 25 mmHg and pulmonary artery wedge pressure ≤ 15 mm Hg on the basis of right heart catheterization), researchers explored the links between soluble neprilysin (sNEP) and natriuretic peptide, hemodynamics (e.g. parameters of echocardiography and right heart catheter) or prognosis (all-cause mortality). They found no significant correlations between sNEP and B-type natriuretic peptide, N-terminal proBNP, and high-sensitivity troponin I, as seen in laboratory data. Also, the higher NEP group vs the lower NEP group showed comparable all-cause mortality rates, as seen in the Kaplan–Meier analysis. In PH patients, all-cause mortality was not predicted by sNEP in the Cox proportional hazard analysis. Overall, in patients with PH, no correlation was seen between circulating sNEP and natriuretic peptide, hemodynamic parameters, or prognosis.