de Gonzalo-Calvo D, et al. - In this case-cohort study, researchers used follow-up data from the REGICOR (Registre Gironí del Cor) population-based cohort to investigate if a link between circulating sLRP1 levels and future coronary events exists. They also determined if the predictive capacity of the REGICOR risk function could be improved with circulating sLRP1 levels. Overall 117 individuals who presented with angina or fatal or non-fatal myocardial infarction out of 5,404 subjects aged between 35 and 74 years without previous history of cardiovascular disease were included. As a subcohort (including 14 patients who presented with coronary events), 512 subjects were randomly selected. Findings revealed plasma sLRP1 was independently correlated with the incidence of coronary events. However, it did not improve the predictive ability of the REGICOR risk function.