Margioula-Siarkou G, Margioula-Siarkou C, Petousis S, et al. - Researchers conducted this meta-analysis with the aim to determine the value of soluble endoglin as predictor of preeclampsia separately at each pregnancy trimester, therefore examining its potential utility as diagnostic biomarker in preeclampsia. Researchers searched MEDLINE, SCOPUS, Cochrane CENTRAL and ClinicalTrials.gov identifying overall 20 studies for inclusion in the meta-analysis, enrolling 1,146 preeclamptic and 1,675 normotensive pregnant women. Findings revealed consistently higher soluble endoglin levels in preeclamptic compared with normotensive pregnant women almost throughout pregnancy. Results here strongly suggest the potential utility of soluble endoglin as a predictor of preeclampsia.