Kohanski MA, et al. - As IL-25 can function as an early signal for the respiratory Type 2 response characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), researchers investigated whether the solitary chemosensory cell (SCC) is the predominant source of IL-25 in the sinonasal epithelium. To interrogate polyp and turbinate tissue from patients with CRSwNP, they used flow cytometry and immunofluorescence for SCCs and IL-25. An expansion of a solitary chemosensory cell population, that was the source of epithelial IL-25, was seen in inflammatory sinus polyps but not adjacent turbinate tissue.