Panth N, et al. - Using data from the National Cancer Database (NCDB), researchers conducted a retrospective cohort study to evaluate the correlation of the implementation of the Affordable Care Act (ACA) with insurance status across socioeconomic and demographic subpopulations of head and neck cancer (HNC) patients. In total, 131,779 HNC patients were identified in the pre-ACA (77,071) and post-ACA (54,708) periods. Overall, 98,207 candidates were men and 33,572 were women, with 73,124 being aged between 50 to 64 years. The data presented in this work showed a significant link between ACA implementation and the percentage reduction in uninsured patients. Compared with older adults and residents of high-income areas, young adults and those residing in low-income zip codes experienced a significantly higher rate of insurance uptake. This indicates that coverage expansions enacted by the ACA are not only linked to increased access to care among the broader HNC population but may also provide a greater benefit to historically limited insurance coverage subpopulations.