SMS messaging to improve retention and viral suppression in prevention of mother-to-child HIV transmission (PMTCT) programs in Kenya: A 3-arm randomized clinical trial
PLoS Medicine May 29, 2021
Kinuthia J, Ronen K, Unger JA, et al. - For providing HIV and maternal child health (MCH) care support to pregnant and postpartum women living with HIV (WLWH), short message service (SMS) could be used. Researchers conducted a 3-arm randomized trial among 824 pregnant WLWH in Kenya comparing 1-way SMS (in which participants could receive SMS but not respond) and 2-way SMS (in which participants could receive and send SMS to nurses) to no treatment control. In guidance of inputs from WLWH who had previously attended prevention of mother-to-child HIV transmission (PMTCT) programs, they integrated messages about HIV treatment into an existing interactive SMS platform for MCH. WLWH were followed from pregnancy to 2 years postpartum and evaluation was performed of impact of SMS on long-term timely attendance at clinic visits, retention, viral suppression, and infant HIV-free survival. Findings revealed that 1-way or 2-way SMS did not have significant effect on HIV viral load (VL) nonsuppression (9.6% in control vs 11.2% in 1-way and 8.5% in 2-way), on-time clinic appointment attendance (88.2% in control vs 88.6% in 1-way and 88.8% in 2-way), and infant HIV or death (2.6/100 person-years (py) in control vs 2.3/100 py in 1-way and 4.1/100 py in 2-way).
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