Cadham CJ, et al. - In view of the current guidelines recommending delivery of smoking cessation interventions with lung cancer screening (LCS), researchers sought for data that may assist clinicians and policy-makers in determining cessation interventions in this setting. For this systematic review and meta-analysis, 3,813 abstracts were independently screened by three investigators and 332 were identified for full-text review. Of these, they included and grouped 85 trials into categories based on the primary intervention: electronic/web-based, in-person counseling, pharmacotherapy, and telephone counseling. At 6-month follow-up, all the interventions led to a significant increase in the odds of abstinence suggesting these interventions as promising for implementation in the LCS setting. Compared to the general population, the cases display lower cessation estimates. Outcomes suggest multi-modality interventions as the most efficacious. At 12-months, two intervention categories (in-person counseling and pharmacotherapy) showed cessation persistence.