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Smoking and risk of fractures requiring hospitalization in hemodialysis patients: A nationwide cohort study in Japan

Nephrology Dialysis Transplantation Oct 30, 2021

Wakasugi M, Kazama JJ, Nitta K, et al. - In patients receiving hemodialysis, smoking was revealed as a significant risk factor for any fracture necessitating hospitalization.

  • A total of 154,077 hemodialysis patients [64.2% men; mean age, 68 years; current smokers= 19,004 (12.3%)] were followed for 1 year.

  • Follow-up revealed occurrence of 3,337 fractures needing hospitalization (1,201 hip, 479 vertebral, and 1,657 other fractures) in 3,291 patients.

  • In multivariable logistic regression analysis, current smokers had a 1.25-fold higher risk of any fracture requiring hospitalization than non-smokers in a fully adjusted model.

  • Similar results were observed on propensity score matching (odds ratio, 1.25).

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