Koyanagi YN, et al. - Via conducting a pooled analysis of 10 population-based cohort studies, researchers assessed the link between smoking and pancreatic cancer risk in a Japanese population, with special emphasis on assessing sex differences. Cox proportional hazards regression was used to calculate study-specific hazard ratios (HRs) and 95% CIs. They used a random effects model to pool these estimates in order to calculate summary HRs. For every 10 pack-years, significant 6% and non-significant 6% increases in pancreatic cancer risk were noted in males and females, respectively. According to findings, smoking is related to pancreatic cancer risk and there exist potential sex differences. In order to prevent pancreatic cancer, the authors suggested that it would be beneficial, particularly in males, to stop smoking.