Izutsu N, et al. - In view of the previous observations regarding spotty hyperintense lesions in the region of the perforating arteries on peri-ictal diffusion-weighted imaging (DWI), researchers investigated focal intensities on peri-ictal DWI, and evaluated the clinical significance of these lesions. They realized that diffusion hyperintense lesions (DHLs) detected on peri-ictal DWI might represent incidental acute cerebral microinfarcts in the aging brain, especially in patients with small vessel disease. Patients with DHLs were more frequently older in age, had atrial fibrillation, and coronary artery disease, and had more severe deep white matter hyperintensity or leukoaraiosis compared to patients without DHLs.