Jung JH, et al. - The prognostic advantage of anatomical resection (AR) over nonanatomical resection (NAR) for hepatocellular carcinoma (HCC) was investigated according to the multiplication of α-fetoprotein, des-γ-carboxyprothrombin, and tumor volume (ADV) scores. Analyzing 1572 patients who underwent curative resection for solitary HCC of 2.0 to 5.0 cm between 2006 and 2014, they identified that AR in patients with ADV score ≤4 log or absence of microvascular invasion was prognostically beneficial. Compared to NAR, AR appears more beneficial for patients with less aggressive tumor biology, thus AR was reasonably indicated in these patients.