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Small for gestational age and risk of childhood mortality: A Swedish population study

PLoS Medicine Jan 09, 2019

Ludvigsson JF, et al. - Authors evaluated 3,795,603 non-malformed singleton live births and 2,781,464 full siblings born between January 1, 1973, and December 31, 2012, in a Swedish population study to assess how small for gestational age (SGA) status is correlated with increased chances of stillbirth and neonatal mortality from 28 days to <18 years. They observed the crude mortality rate of 5.32 per 10,000 person-years in infants born with severe SGA, 2.76 in children born with moderate SGA, and 1.93 in non-SGA kids. They found an association between severe SGA and a higher risk of childhood death past the neonatal period, with death from infection and neurologic diseases carrying the highest risk. Researchers stressed the need for primary preventive approaches to reduce the long-term risks of intrauterine growth restriction.

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