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Small dense low-density lipoprotein cholesterol predicts cardiovascular events in liver transplant recipients

Hepatology Jan 31, 2019

Siddiqui MB, et al. - Given that cardiovascular disease (CVD) is an key cause of morbidity and mortality following liver transplantation (LT) and LT is linked with dyslipidemia, investigators assessed the effect of small dense low-density lipoprotein cholesterol (sdLDL-C) on CVD events. Study participants were 130 patients who had detailed lipid profile including traditional lipid parameters and sdLDL-C and were then followed for CVD events. The mean age of the cohort was 58±11 years. According to the data, nonalcoholic steatohepatitis and hepatitis C were the most common etiologies of liver disease, and small dense LDL-C was an independent predictor CVD events while LDL-C was not. This association was independent of diabetes, hypertension, gender, ethnicity, liver disease, obesity and statin use. SdLDL-C may be a useful clinical tool for risk-stratifying and managing patients following LT.

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