Clattenburg EJ, et al. - Researchers performed a comparison of the analgesic efficacy and incidence of side effects when low-dose (0.3 mg/kg) ketamine (LDK) is administered as a slow infusion (SI) over 15 minutes vs an intravenous push (IVP) over 1 minute. In this prospective, randomized, double-blind, double-dummy, placebo-controlled trial of adult ED patients presenting with moderate to severe pain, they noted psychoperceptual side effect in most patients who were administered LDK, regardless of administration via SI or IVP. However, significantly fewer moderate or greater psychoperceptual side effects and hallucinations were observed among patients receiving LDK as an SI with equivalent analgesia.