Valrie CR, et al. - Researchers examined how sleep affects the correlation between pain and healthcare use (HCU) in youth with sickle cell disease (SCD). They hypothesized that poor sleep would be correlated to higher HCU and would strengthen the correlation between high pain frequency and more HCU among youth with SCD. From 3 regional pediatric SCD clinics, they enrolled 96 youth with SCD (aged 8 to 17 y) and their guardians. The Structured Pain Interview for parents was conducted to assess the youth’s pain frequency and HCU, and youth wore a sleep actigraph for up to 2 weeks to evaluate sleep duration and sleep efficiency. Incongruous with hypotheses, they identified no direct relation of poor sleep with HCU. Also, longer sleep duration seemed to strengthen the link between high pain frequency and more emergency department visits. The analysis suggests a protective effect of good sleep for better matching pain to HCU. Outcomes support the necessity to recognize and address the role played by sleep in responding to SCD pain in pediatric groups.