Sun ZW, Kim JH, Kim SH, et al. - Researchers conducted the study for analyzing the role of natural killer T (NKT) cells in atopic dermatitis (AD) development, particularly in the skin. Global proteomic and transcriptomic analyses were conducted by using skin and blood from human healthy–controls and patients with AD. In human AD and mouse AD models, levels of CXCR4 and CXCL12 expression in skin NKT cells were analyzed. Global transcriptomic and proteomic analyses revealed that CXCR4 and its cognate ligand CXCL12 were significantly upregulated in the skin of humans with AD. Findings suggested that CXCR4 ⁺ tissue-resident NKT cells can form a niche in which CXCL12 is highly expressed, which may contribute to AD.