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Skin pH–dependent Staphylococcus aureus abundance as predictor for increasing atopic dermatitis severity

Allergy Jul 10, 2020

Hülpüsch C, Tremmel K, Hammel G, et al. - Given that atopic eczema (atopic dermatitis, AD) is distinguished by disrupted skin barrier related to high skin pH and skin microbiome dysbiosis, because of high Staphylococcus aureus loads, particularly during flares, and since S aureus exhibits optimal growth at neutral pH, so, researchers undertook this pilot study to determine the longitudinal interplay between these factors and AD severity. This study included 6 AD patients and 6 healthy controls. Emollient (with either basic pH 8.5 or pH 5.5) was applied double‐blinded twice daily to participants for 8 weeks. Findings revealed tight regulation of skin pH by intrinsic factors, and showed that the abundance of S aureus was limited by skin pH. Over the study span, a rise in AD severity was predicted by high baseline S aureus abundance. This emphasizes the worth as well as potential of sustained intervention concerning the skin pH.

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