Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): A factorial, multicentre, cluster-randomised trial
The Lancet Mar 01, 2020
Skjerven HO, Rehbinder EM, Vettukattil R, et al. - A factorial, multicentre, cluster-randomized trial was designed to determine whether either regular skin emollients utilized from 2 weeks of age or early complementary feeding introduced between 12 and 16 weeks of age, reduced development of atopic dermatitis by age 12 months in the general infant population. This trial was performed at Oslo University Hospital and Østfold Hospital Trust, Oslo, Norway; and Karolinska University Hospital, Stockholm, Sweden. This study recruited a total of 2,697 women between Dec 9, 2014, and Oct 31, 2016, from whom 2,397 newborn infants were included from April 14, 2015, to April 11, 2017. The study indicated that neither early skin emollients nor early complementary feeding decreased the growth of atopic dermatitis by age 12 months. This research does not advocate the use of these interventions to prevent atopic dermatitis by 12 months of age in infants.
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