Yang G, et al. – The clinicians applied a whole–exome sequencing (WES), in order to identify genetic variants associated with osteonecrosis of jaw (ONJ) in patients of European ancestry treated with intravenous (IV) bisphosphonates (BPs). They illustrated that the SIRT1/HERC4 locus on Chromosome 10 to be associated with IV BPs related ONJ and two promoter single nucleotide polymorphisms (SNPs) that might be the potential genetic markers for this association.