Strychowsky JE et al. – This institutional review board–approved retrospective review aimed to establish the emerging therapeutic role of sirolimus for the treatment of patients with refractory cervicofacial malformation. The results of the study demonstrated that sirolimus was often efficacious in the management of cervicofacial lymphatic malformations (LM) with few adverse events. However, further studies are required to evaluate long–term follow–up, durability of response and coordination of sirolimus before procedural therapies.