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Single-nucleotide polymorphisms of VEGF-A and VEGFR-2 genes and risk of infantile hemangioma

International Journal of Dermatology Jul 12, 2018

Oszajca K, et al. - Researchers assessed the influence of selected polymorphisms in the genes coding for vascular endothelial grow factor (VEGF)-A (+405 G/C, rs2010963; +936 C/T, rs3025039) and its receptor VEGFR-2 (+1416 T/A, rs1870377; –271 G/A, rs7667298) on the susceptibility to infantile hemangioma. For infantile hemangioma, none of the investigated VEGF-A and VEGFR-2 genes polymorphisms was found to be an independent prognostic marker. Nonetheless, a significantly lower risk of infantile hemangioma (IH) was seen in the individuals carrying at least one G allele of +405 G/C VEGF-A polymorphism.
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