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Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease

Journal of Periodontal Research May 14, 2018

Schulz S, et al. - Experts evaluated the effect of antisense noncoding RNA in the INK4 locus (ANRIL) SNPs rs133049 and rs3217992 on the severity of periodontitis and the prior history of coronary events, as well as on the incidence of additional adverse CV events among cardiovascular patients (CV angiographically proven ≥50% stenosis of a main coronary artery). In CV patients, SNPs in ANRIL were not risk modulators for severe periodontitis and history of CVD. Prognostic power for further CV events within 3 years of follow-up was seen by the AA genotype of ANRIL SNPs rs3217992.

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