D'hooghe MB, et al. - In this retrospective study, researchers examined the contribution of volume measures obtained with magnetic resonance scans performed as part of regular care to predict measures of cognitive and physical multiple sclerosis (MS) disability in a real-world setting. Study participants included 470 adults with diagnosed MS. The data presented in this work showed a single brain volumetric assessment contributes to the prediction of MS-related disability, with distinct patterns for Expanded Disability Status Scale (EDSS) as a measure of physical disability, and Symbol Digit Modalities Test (SDMT) as a measure of cognitive disability. A threshold effect was found for the lowest brain volumes with regard to SDMT worsening over time.