Prasad R, et al. - In this prospective, controlled, and double-blind study, researchers determined the impact of two dose regimens of tranexamic acid in attenuating perioperative blood loss and the amount of allogenic blood transfusion in 60 patients electively posted for abdominal oncosurgical procedures. In a randomized manner, a single bolus dose of tranexamic acid (10 mg/kg) (Group A), a bolus dose of tranexamic acid (10 mg/kg) followed by infusion (1 mg/kg/h) till 4 h postoperatively (Group B), and a bolus followed by infusion of normal saline (group C) was administered to patients. Findings revealed more effective reduction in post-operative blood loss with tranexamic acid when it was used as a bolus followed by an infusion continued in the postoperative period than its use as a single intravenous bolus in abdominal tumor surgery. In all the three groups, intraoperative blood loss did not vary markedly. A significant reduction from the baseline was seen in hemoglobin and hematocrit levels measured at different postoperative time intervals in the control group vs the tranexamic acid groups together.