Campbell A, et al. - Researchers aimed to ascertain the effect of vitamin B12 supplements on musculoskeletal symptoms such as pain and arthralgias induced by aromatase inhibitors (AIs) in women with early-stage breast cancer. They also correlated the response with serum and inflammatory biomarkers. Majority of patients who had a diagnosis of invasive breast cancer (Stages I-III), and were experiencing significant musculoskeletal symptoms associated to AIs were treated at the Texas Tech Breast Care Center following the approval by the Institutional Review Board (IRB). Administration of 2500 mcg of sublingual vitamin B12 daily for 90 days to the participants resulted in improved average pain scores by 34% at 3 months compared to baseline. Findings thereby suggest that vitamin B12 reduces pain and improves quality of life among these patients.